Significance of Platelet Indices and Ratios in Different Degrees of Burn

Brief Summary

Detailed Description

Burns are a major traumatic pathology characterized by tissue destruction and cellular degradation resulted by energy transfer and mainly affect skin, which serve as significant cause of morbidity and mortality. burns are classified as first,second and third degree depending on how deep and severe they penetrate the skin surface. Platelets play important role in primary homeostasis, thrombosis, inflammation and tissue regulation in the processes of wound healing. Platelets can contact exposed collagen and extra cellular matrix and releasing clotting factors to achieve homeostasis as well as essential growth factors and cytokines to repair the wound.In clinical, Platelet-rich plasma (PRP) is a concentrate of autologous platelets,has been used to effectively accelerate burn wound healing Platelet indices (PI), markers of platelet activation, are parameters obtained daily as a part of an automatic blood count, Platelet indices are related to platelets morphology and proliferation kinetics. Most commonly assessed platelet indices include the mean platelet volume (MPV), mean distribution width(PDW),Platelet larger cell ratio (PLCR) ,platelet crit (PCT), mean platelet mass (MPM),mean platelet component (MPC),Platelet component distribution width (PCDW) and immature platelet fraction (IPF). The ratio of red blood cell distribution width (RWD) and platelet (PLT) (RPR) is considered an inflammation biomarker associated with the poor prognosis of number of diseases. There is two studies about PRP related to prognosis of major burn injury . results indicate that RPR-as an inflammatory index- can be used as a biomarker for prognosis of adult patients with major burn injuries. Blood-based platelet parameters, due to their fairly easy accessibility and inexpensive methods of measurement, seem to be on the rise as potential novel biomarkers of numerous ,both acute and chronic disease. However, To date ,there are no data on the significance of platelets indices in evaluation with different degrees of burn .In this study we will evaluate the significance of platelet ratios and indices in different degrees of burn.

Primary Outcomes