NCT07106268进行中（未招募）不适用
Aqueous Humor Proteome Analysis in Conbercept-treated Retinal Vein Occlusion With Macular Edema
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Central retinal thickness
研究概览
简要总结
the goal of this observational study is to the find the molecular mechanisms underlying the prognosis process of Retinal vein occlusion in patients with retinal vein occlusion . The main question it aims to answer is:
What are the changes in protein in the aqueous humor during treatment in patients who are sensitive to anti-VEGF drug therapy?
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cystic or diffuse edema in the macular area, retinal vein tortuous dilation with hemorrhage
- •Optical coherence tomography (OCT) examination showed that the macular area was raised, edema and thickened
- •Monocular disease, baseline central retinal thickness (CRT) ≥ 250mm
- •Intravitreal injection, laser photocoagulation and blood circulation and blood stasis removal drugs were not treated before surgery
- •The patient had normal blood pressure, negative urine protein, normal liver and kidney function, and normal electrocardiogram
排除标准
- •Patients with fluorescein fundus angiography (FFA) showing a large area (10 optic disc areas) without perfusion requiring retinal photocoagulation
- •Patients with chronic dacryocystitis, glaucoma, cataract, severe proliferative vitreoretinopathy or vitreous hemorrhage, epi macular membrane or macular ischemia, diabetic retinopathy, age-related macular degeneration, ocular trauma and other diseases
- •Intravitreal therapy or laser photocoagulation with corticosteroids or anti-VEGF drugs within three months before the study
结局指标
主要结局
Central retinal thickness
时间窗: March 2023 - June 2024
The Heidelberg Optical Coherence Tomography scanner was used to detect the central retinal thickness in patients
次要结局
- Best corrected visual acuity(March 2023 - June 2024)
研究者
Chuanzhen Zheng
Principal investigator
Tianjin Medical University Eye Hospital
研究点 (1)
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