Trends of Mastectomy and Breast-Conserving Surgery and Related Factors in Female Breast Cancer Patients Treated at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, 2009-2017
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 335
- 试验地点
- 1
- 主要终点
- Prevalence of each of mastectomy and breast-conserving surgery
研究概览
简要总结
Breast cancer is the most common cancer in women across the world, accounting for 25.2% of cancer cases among females and 14.7% of cancer-related deaths among females worldwide. The survival rates are markedly lower in the developing countries compared to developed countries, as well as the age at diagnosis. Core management of breast cancer includes surgical removal of the tumor either by breast-conserving surgery (BCS) or mastectomy (removal of the whole breast). Choosing between these two procedures may be influenced by factors that have yet to be studied in Saudi Arabia. The investigators aimed to determine the prevalence of BCS and mastectomy and the factors that may influence the choice of procedure. This retrospective study was carried out by reviewing the records of female breast cancer patients who underwent BCS or mastectomy at King Abdulaziz University Hospital between 2009 to June 2017, excluding those with metastasis (distant spread of the cancer) or recurrence. Using frequencies for the rate, and multivariate tests, the investigators analyzed different demographic, clinicopathological, and radiological factors to detect correlations with procedure choice.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female, diagnosed with breast cancer, underwent surgery on the breast tumor in King Abdulaziz University Hospital
排除标准
- •Patients with metastatic breast cancer or recurrence of the cancer before the surgery
结局指标
主要结局
Prevalence of each of mastectomy and breast-conserving surgery
时间窗: 2009-2017
The percentage of of patients who underwent each surgery
次要结局
- The relationship between the choice of procedure and the tumor's size (in centimeters)(2009-2017)
- The relationship between the choice of procedure and the tumor's stage (using the 7th "American Joint Committee on Cancer"'s staging guidelines)(2009-2017)
- The relationship between the choice of procedure and the tumor's histological grade (using the Nottingham Histologic Score system)(2009-2017)
- The relationship between the choice of procedure and the tumor's receptor status (whether it is positive for estrogen, progesterone, and/or human epidermal growth factor receptor 2)(2009-2017)
- The relationship between the choice of procedure and the use of preoperative chemotherapy (also called "neoadjuvant chemotherapy")(2009-2017)
- The relationship between the choice of procedure and the tumor's laterality (right versus left breast cancer)(2009-2017)
- The relationship between the choice of procedure and the tumor's focality (whether it is composed of more than one mass)(2009-2017)
- The relationship between the choice of procedure and the patients' age (in years)(2009-2017)
- The relationship between the choice of procedure and the tumor's centricity (whether it involves more than one quadrant of the breast)(2009-2017)
- The relationship between the choice of procedure and having preoperative magnetic resonance imaging of the breast and its findings(2009-2017)
研究者
Zuhoor K. AL-Sharif
Professor
King Abdulaziz University