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Clinical Trials/NCT04186910
NCT04186910
Unknown
Not Applicable

Increasing Physical Activity in Recovered Persons With Multiple Sclerosis Through Daily Sensor Based Feedback and Weekly Focus Group Meetings: A Feasibility and Pilot II Study

Fondazione Don Carlo Gnocchi Onlus1 site in 1 country20 target enrollmentJuly 1, 2019

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Rehabilitation
Sponsor
Fondazione Don Carlo Gnocchi Onlus
Enrollment
20
Locations
1
Primary Endpoint
The 2 minute walking test
Last Updated
6 years ago

Overview

Brief Summary

The aim of htis study is to investigate the post intervention effects of daily feedback on actual physical activity levels derived from a wristworn accelerometer FITBIT combined with self-management training on in-clinic physical activity in persons with moderate to severe disability from MS.

Detailed Description

Evidence from various sources indicate that physical activities and mobility practice are beneficial to maintain or increase functional levels in persons with Multiple sclerosis. Even so persons with moderate and severe disability from Multiple sclerosis are less active in daily life than their healthy counterparts. Also during hospital stay persons with MS tend to remain relatively sedentary outside of their rehabilitation sessions. Feedback about physical activity enabled by wearable sensors combined with behavioral strategies to improve self-efficacy and motivation are potential method increase physical activity in hospital inpatients. The primary purpose of this feasibility and interventional study was to determine whether a minimalist physical activity tracker-based feedback and self efficacy training would lead to an increase in physical activity, mobility and quality of life measures during recovery in a group of persons with MS compared to a control group that does not receive feedback. Secondary purpose was to verify if this intervention during recovery would lead to increased perceived physical activity in daily home life after discharge and over longer periods (Follow up at 6 weeks). The study participants will be 60 persons that have moderate to severe disability due to MS, that are admitted to MS Centre of the Santa Maria Nascente Institute, Don Gnocchi Foundation (Milan, Italy). Participants will all receive standard rehabilitation offered in the center. All participants will wear the accelerometer device (FitBit Charge tracker, FitBit Inc, CA, USA) 24 hours per day in order to measure physical activity levels during their hospital stay (3-4 weeks. The participants will be randomized to a group that has no feedback of physical activity level and a group that will have an active feedback intervention (AF). The active feedback intervention will consist of daily feedback, received through a Fitbit application downloaded on their telephones, on whether or not their target activity level was met and how far they were from the target. Additionally, the participants will participate in weekly meeting group focused on enhancing behavioral strategies to increase self-efficacy and motivation. Covariates such as age, sex, stage of change for physical activity behavior, clinical mobility, fatigue, health perception and goal commitment will be measured in all 60 participants both pre and post the intervention/hospital recovery period. The long-term effects on daily perceived functional mobility and self-efficacy will be investigated six weeks after discharge through questionnaires during a telephone call.

Registry
clinicaltrials.gov
Start Date
July 1, 2019
End Date
September 2020
Last Updated
6 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of MS according to the McDonald's criteria McDonald Criteria 2010
  • EDSS score \>4.5-7
  • Freedom from relapses and steroid treatment for at least 1 month
  • Ability to walk at least 10 meters independently with or without support
  • MS without relapses in the last 3 months

Exclusion Criteria

  • Mini Mental State Examination (MMSE) score \< 20
  • The presence of disabling pain or severe deficit of visual acuity
  • The presence of severe deficit in communication and severe dysmetry

Outcomes

Primary Outcomes

The 2 minute walking test

Time Frame: Change on the measue will be measured. Will be applied at Day 1 and after 4 weeks

The 2 minute walking test is used to understand functional mobility. A smaller distance covered (in meters) represents a worse outcome.

The Self-Efficacy in Multiple Sclerosis Scale

Time Frame: Change on the measure will be measured. Will be applied at Day 1, after 4 weeks and after 10 weeks

The Self-Efficacy in Multiple Sclerosis Scale is a questionnaire of perceived self-efficacy of MS patients

Number of passes with Fitbit wristband

Time Frame: Change from number of passes at baseline to number of passes after 4 weeks will be measured.

A Fitbit wristband consists of an accelerometer and a memory unit and is used to collect mobility data, in the form of number of passes. More passes carried out during the period of wearing the wristband the better.

Secondary Outcomes

  • The 10 meters walking scale(Change from Day 1 to day 28 will be measured. Will be applied at the Day 1 and after 4 weeks)
  • The Short Form-12 questionnaire(Change from Day 1 to 4 weeks and until 10 weeks will be measured. Will be applied at baseline Day 1 after 4 weeks and after 10 weeks)
  • The Fatigue severity Scale(Change from Day 1 to 4 weeks and until 10 weeks will be measured. Will be applied at the Day 1, after 4 weeks and after 10 weeks)
  • The EQ-5D visual analogue scale(Change from Day 1 to 4 weeks and until 10 weeks will be measured. Will be applied at the Day 1, after 4 weeks and after 10 weeks)
  • The Twelve Item MS Walking Scale(Change from Day 1 to 4 weeks and until 10 weeks will be measured. Will be applied at the Day 1, after 4 weeks and after 10 weeks)
  • The Physical Activity Disability Survey-Revised questionnaire(Change from Day 1 to 4 weeks and until 10 weeks will be measured. Will be applied at the Day 1, after 4 weeks and after 10 weeks)

Study Sites (1)

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