Influence of Propofol on Alveolar Macrophage Immunity in Asthmatic Patients Undergoing General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Alveolar macrophage viability assay
研究概览
简要总结
The change of airway responsiveness and alveolar macrophage (AM) immunity occurs during the pathogenesis of asthma. Macrophage-associated airway protection in patients with asthma is affected positively or negatively by propofol general anesthesia. The investigators hypothesized that the effects of propofol on asthmatic AMs and corresponding airway reactivity in vivo is different from the in vitro research. Through in vivo airway hyperresponsiveness (AHR) observation and clinical investigation of AM immune functions from asthma patients undergoing propofol general anesthesia to clarify the precise effects of propofol on AM immunity, and to provide theoretical basis for the clinical administration of propofol in asthmatic patients. This would optimize the practice of clinical anesthesia, especially for those with the tendency of AHR.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA physical status I-II;
- •Aged from 18 years to 45 years;
- •Patients with or without asthma or a history record of asthma;
- •Undergoing elective lumpectomy under general anesthesia.
排除标准
- •Allergy to propofol and opioids, a history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records;
- •Participants younger than 18yr，older than 45yr or pregnancy;
- •Those who were not willing to or could not finish the whole study at any time;
- •The PACU assessing score was under 6 on a scale of 10 (measuring somnolence, respiration, movement, color, and blood pressure on 0-2 scales), and arterial oxygen saturation measured by pulse oximetry (SaO2) was 92% or lower (supplemental oxygen was permitted).
研究组 & 干预措施
1
Propofol general anesthesia for asthmatic patients
干预措施: 2,6-Diisopropylphenol (Drug)
2
Propofol general anesthesia for non-asthmatic patients
干预措施: 2,6-Diisopropylphenol (Drug)
结局指标
主要结局
Alveolar macrophage viability assay
时间窗: One day prior to the surgery, immediately after anaesthesia, at the beginning and the end of the operation and one day after surgeries.
次要结局
- Alveolar macrophage phagocytosis Assay(One day prior to the surgery, immediately after anaesthesia, at the beginning and the end of the operation and one day after surgeries.)
- Alveolar macrophage cytokine Assay(One day before the surgery, immediately after anaesthesia, at the beginning and the end of the operation and one day after surgeries.)
- Mean airway pressure(Before operation to the end of the surgery.)
- Curve shape of CO2(Before operation to the end of the surgery.)
- End-tidal CO2(Before operation to the end of the surgery.)