Maternal pharmacokinetics and pharmacodynamics of nicardipine (iv) during treatment of severe hypertension in pregnancy. - Nicardipine PkPd study

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月29日

适应症

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•Pregnant patients with preeclampsia (hypertension and protein/creatinine ratio >= 30mg/mmol or >= 300mg protein/24hours) complicated with severe hypertension (systolic bloodpressure >= 160mmHg and/or diastolic blood pressure >= 110mmHg);gestational age >= 20 weeks;working knowledge of Dutch language

•Fetal indication for immediate delivery, ie. signs of fetal distress: spontaneous repeated persistent unprovoked decelerations on CTG;Fetal death or major fetal congenital anomalies or estimated fetal weight below 500 grams;Placental abruption;Concomitant medication: nifedipine, cimetidine, labetalol;Clinically relevant pulmonary edema, defined as clinically relevant respiratory failure or severe respiratory distress requiring oxygen supplementation (more than 10 litres), with rales and/or pulse oximetry of <94% on room air;Eclampsia;Suspicion of (sub)capsular liverhematoma on physical examination;Renal failure (creatinine clearance < 40 mL/min)
•Suspicion of cerebro-vascular incident on physical examination
•Suspicion of trombo-embolism on physical examination
•Other severe maternal complications
•Maternal age <16 years
•Mentally incapacitated patient
•Impossible to place an intra-arterial catheter.

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