In vitro measurements in pump systems for extracorporeal circulation with altered whole blood viscosity
- Conditions
- basic research regarding hemolysis, anticoagulation, inflammation and pump settings in extracorporeal circulation
- Registration Number
- DRKS00017402
- Lead Sponsor
- niversitätsherzzentrum Freiburg - Bad Krozingen, Klinik für Herz- und Gefäßchirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Age > 15 years and medically indicated blood withdrawal
Exclusion Criteria
blood volume below 300 ml
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method free hemoglobin after 6 hours (calculation of N.I.H. [Normalized Index of Hemolysis] and M.I.H. [Modified Index of Hemolysis])
- Secondary Outcome Measures
Name Time Method - concentration of inflammatory proteins (e.g. TNF-alpha, IL1beta, IL-6, IL-8) after 6 hours<br>- concentration of neutrophil elastase after 6 hours<br>- von-Willebrand Factor (VWF) antigen, VWF-Multimere after 3 and 6 hours<br>- analysis of thrombocyte function after 3 hours<br>- Quick, pTT, Fibrinogen, Antithrombin III, Protein C and Protein S after 6 hours