Validation of a single forehead sensor against polysomnography and evaluation of the introduction of a circadian lighting solution on sleep, circadian rhythms and recovery in the intensive care unit (ICU)

Not Applicable

Recruiting

Conditions: Delirium
Sleep deprivation in ICU
Circadian rhythm disturbance in ICU
Public Health - Health service research
Mental Health - Other mental health disorders
Neurological - Other neurological disorders

Registration Number: ACTRN12622000854730

Lead Sponsor: Metro North Hospital and Health Service

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

• Adult patients (age greater than or equal to 18 years)
• Written informed consent by patient or legally authorised person
• ICU length of stay >2 days at time of recruitment to participate and expected to remain in ICU for a minimum of 2-3 further days
• Arterial or central venous line in situ to allow blood tests to be collected

Exclusion Criteria

• Age <18 years
• Unable or unwilling to provide consent to participate
• Deeply and moderately sedated patients (RASS score -3, -4 or -5)
• General anaesthetic, drug overdose or alcohol intoxication in the preceding 24 hours
• Recent substantial neurological insult (e.g. stroke)
• Death is deemed imminent
• Significant cardiovascular or respiratory instability as determined by the treating therapist or medical staff
• Patients who are deemed to be agitated, aggressive or display unpredictable behaviours
• Patients with an active infection by a resistant organism
• Patients with an open sternum

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maintenance of circadian rhythms between improved and unmodified ICU bedspaces. Circadian rhythms will be assessed by 1) analysis of routinely monitored physiological data collected via the bedside patient monitor and downloaded from the electronic medical records (body temperature, heart rate, heart rate variability and blood pressure), 2) sleep (via PSG), 3) blood tests every 4 hours (cortisol, melatonin, IGF1 levels, untargeted RNA-sequencing, proteomics analysis, and expression of circadian clock genes in white blood cells).[ For a 24 hour period between day 2 and 4 after recruitment to participate.]

Secondary Outcome Measures