Dynamic Measurement of Cerebrospinal Fluid in Healthy Subjects: Pilot Study

Poitiers University Hospital1 site in 1 country15 target enrollmentSeptember 24, 2025

ConditionsCerebrospinal Fluid Healthy Subjects or Volunteers

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cerebrospinal Fluid
Sponsor: Poitiers University Hospital
Enrollment: 15
Locations: 1
Primary Endpoint: To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1)
Status: Completed
Last Updated: 3 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This research will enhance our knowledge and understanding of Cerebrospinal Fluid (CSF) circulation around the Central Nervous System (CNS) (brain and spinal cord).

The main objective is to obtain flow velocities using Phase Contrast (PC) MRI over the entire subarachnoid space (SAS). This will enable us to develop and validate a numerical model of the SAS.

Registry

clinicaltrials.gov

Start Date

September 24, 2025

End Date

December 17, 2025

Last Updated

3 months ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Poitiers University Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age ≥ 18 years at the time of agreement
•Free subject, without guardianship or curatorship or subordination
•Patients benefiting from a Social Security scheme or benefiting from it through a third party
•Informed consent signed by the patient after clear and complete information about the study

Exclusion Criteria

•3T MRI contraindications (pacemaker, cochlear implant, metallic splinter, etc)
•History of neurological pathology
•Previous operations involving the central nervous system (spinal surgery, neurological surgery, etc.)
•Current pathology or treatment that may interfere with the CSF or subarachnoid spaces (CSF dysregulation, disc herniation, hydrocephalus, Chiari malformation, etc.)
•Concurrent participation in another clinical research study
•Persons not covered by Social Security or not covered by Social Security through a third party
•Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, adults under legal protection
•Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
•Exclusion criteria during the study:
•\- Discovery of a contraindication to 3T MRI (pacemaker, cochlear implant, metallic splinter, etc)

Outcomes

Primary Outcomes

To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1)

Time Frame: Time PC-MRI will be around 60min

Displacement velocities of CSF will be obtain by Phase Contrats MRI.

Secondary Outcomes

Using morphological MRI to model a digital twin(Time PC-MRI will be around 60min)
To evaluate the velocity displacement of blood about 2 planes (intracranial plane, C2-C3)(Time PC-MRI will be around 60min)