NCT06743347已完成不适用
Dynamic Measurement of Cerebrospinal Fluid in Healthy Subjects: Pilot Study
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1)
研究概览
简要总结
This research will enhance our knowledge and understanding of Cerebrospinal Fluid (CSF) circulation around the Central Nervous System (CNS) (brain and spinal cord).
The main objective is to obtain flow velocities using Phase Contrast (PC) MRI over the entire subarachnoid space (SAS). This will enable us to develop and validate a numerical model of the SAS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 years at the time of agreement
- •Free subject, without guardianship or curatorship or subordination
- •Patients benefiting from a Social Security scheme or benefiting from it through a third party
- •Informed consent signed by the patient after clear and complete information about the study
排除标准
- •3T MRI contraindications (pacemaker, cochlear implant, metallic splinter, etc)
- •History of neurological pathology
- •Previous operations involving the central nervous system (spinal surgery, neurological surgery, etc.)
- •Current pathology or treatment that may interfere with the CSF or subarachnoid spaces (CSF dysregulation, disc herniation, hydrocephalus, Chiari malformation, etc.)
- •Concurrent participation in another clinical research study
- •Persons not covered by Social Security or not covered by Social Security through a third party
- •Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, adults under legal protection
- •Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
- •Exclusion criteria during the study:
- •- Discovery of a contraindication to 3T MRI (pacemaker, cochlear implant, metallic splinter, etc)
研究组 & 干预措施
Phase Contrast MRI
Experimental
干预措施: MRI Contrast (Other)
结局指标
主要结局
To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1)
时间窗: Time PC-MRI will be around 60min
Displacement velocities of CSF will be obtain by Phase Contrats MRI.
次要结局
- Using morphological MRI to model a digital twin(Time PC-MRI will be around 60min)
- To evaluate the velocity displacement of blood about 2 planes (intracranial plane, C2-C3)(Time PC-MRI will be around 60min)
研究者
研究点 (1)
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