NCT01268709已完成2 期
Effect of Doxepin and Nortriptyline on Irritable Bowel Syndrome
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 1
研究概览
简要总结
The objective of this randomized triple blind controlled trial is to compare the effects of Doxepin and Nortriptyline on diarrhea predominant irritable bowel syndrome. In this stuy, 75 patients with IBS are randomly assigned to receive Doxepin , Nortriptyline or placebo, a tablet per day, orally, for two months. Abdominal pain, mucus in the stool, incomplete evacuation, and bloating are measured and compared between groups at the baseline and one and two month after the intervention.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of diarrhea predominant irritable bowel syndrome according to ROME criteria
排除标准
- •Gastrointestinal bleeding
- •More than 5% weight loss in the last 6 months
- •Presence of any finding in favor of organic disorders in the lab tests or organic disorder in colonoscopy of high risk patients
研究组 & 干预措施
doxepin
Active Comparator
干预措施: Doxepin (Drug)
nortriptyline
Active Comparator
干预措施: Nortriptyline (Drug)
placebo
Placebo Comparator
干预措施: placebo (Drug)
研究者
研究点 (1)
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