Effects of modafinil, caffeine and methylphenidate on functional brain activity and cognitive performance in healthy volunteers: a randomized, placebo-controlled, double-blind fMRI study.
- Conditions
- Healthy participants
- Registration Number
- DRKS00005219
- Lead Sponsor
- Charité Campus Charité Mitte
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 48
Men
- 18 - 35 years
- Written consent (according to AMG § 40 (1) 3b)
- Good knowledge of German
- right-handedness
- Known hypersensitivity to the study medication
- All contraindications to the study medication: arrhythmia, hyperthyroidism , glaucoma , pheochromocytoma , congestive heart failure , diabetes mellitus, known liver and kidney dysfunction, vascular disease , angina, haemodynamically significant congenital heart disease , cardiomyopathy , myocardial infarction, channelopathies, arterial hypertension , cerebrovascular diseases , such as cerebral aneurysm , vascular abnormalities , including vasculitis and stroke.
- Participation in other clinical trials during or within one month prior to this clinical trial
- Medical or psychological circumstances that may endanger the proper conduct of the trial
- Existing serious somatic diseases, even if they are not covered by the contraindications according to product information
- Existing psychiatric disorders and psychiatric disorders in prehistory
- Smoker or ex-smoker for less than 5 years
- Regular caffeine consumption > 4 cups per day
- Subjects with irregular day -night rhythm (eg shift workers )
- Unwillingness to the storage and disclosure of pseudonymous data as part of the clinical trial
- Accommodation in an institution by court or administrative order (according to AMG § 40 (1) 4 )
- MR contraindications ( eg pacemakers , metallic or electronic implants , metallic splinters , tinnitus, surgical clips )
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method