Using Magnetic Resonance Techniques to Improve the Characterisation and Localisation of Breast Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Institute of Cancer Research, United Kingdom
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Sensitivity of MR techniques in detecting histopathologically-identified multifocal and multicentric lesions
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Objective: To determine the accuracy of multi-functional magnetic resonance (MR) in detecting, localising and characterising satellite lesions in relation to an index breast tumour in order to improve definition of clinical target volume after local excision.
Hypothesis: Pre-operative multi-functional MR has high sensitivity and specificity for localising unsuspected multifocal and multicentric lesions in women diagnosed with early breast cancer.
Investigators
NdeSouza
Professor of Translational Imaging
Institute of Cancer Research, United Kingdom
Eligibility Criteria
Inclusion Criteria
- •Biopsy proven invasive ductal carcinoma of the breast
- •Unifocal disease
- •Patient proceeding to mastectomy
Exclusion Criteria
- •Multifocal disease
- •Previous surgery to ipsilateral breast
- •Neoadjuvant chemotherapy
- •Ferromagnetic implants
- •Claustrophobia
- •Cup size DD or greater
Outcomes
Primary Outcomes
Sensitivity of MR techniques in detecting histopathologically-identified multifocal and multicentric lesions
Time Frame: 4 years
Sensitivity of the MR technique in detecting histopathologically-identified multifocal/centric pre-invasive/invasive disease will be calculated (with 95% confidence intervals)from positive or negative correlates.
Secondary Outcomes
- Closeness of agreement between MR techniques and histopathology in localising satellite lesions relative to the index tumour.(4 years)