Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes

Not Applicable

Completed

Brief Summary: The study is a randomized crossover trial. Current menthol smokers will complete a session with each flavor of an electronic cigarette: menthol and tobacco. The objective of this survey is to assess for flavor preference.

Detailed Description: Participants who report typically smoking menthol cigarettes will be invited to complete a session. Participants will undergo overnight tobacco/nicotine abstinence before the visit (eCO\<12ppm). Participants will then be randomized 1:1 to e-cigarette flavor order (tobacco e-cigarette, menthol e-cigarette). They will complete a 30-minute ad libitum session with the first product, based on randomization, followed by a 1.5 hour standard washout period, followed by a 30-minute ad libitum vaping session with the second product. Throughout each session, puff topography will be measured via a pressure sensor attached to the e-cigarette device. Participants will complete self-report measures of smoking urges and withdrawal symptoms pre- and post-vaping session. In addition, they will complete measures of subjective vaping experience, perceptions of flavor, product demand, and intentions for future use.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Interested in quitting cigarettes in the next 30 days
use of smoking cessation pharmacotherapy in the past 30 days
use of non-cigarette tobacco products in the past 30 days
use of e-cigarettes >5x in lifetime
use of e-cigarettes ≥4 of the past 30 days
weight < 110 lbs
uncontrolled hypertension (systolic BP ≥ 180 or diastolic BP ≥ 105)
pregnant, plans to become pregnant, or breastfeeding
live >10 miles from study site (Fairway CRU)
current enrollment is a research study or program that aims to alter tobacco use

Arm && Interventions

Group	Intervention	Description
Menthol then tobacco	E-cigarette product	A 30-minute session with menthol flavor then a 30-min session with tobacco flavor
Tobacco then Menthol	E-cigarette product	A 30-minute session with tobacco flavor then a 30-min session with menthol flavor

Primary Outcome Measures

Name	Time	Method
Questionnaire Scale "Intentions for Future Use"	during the intervention	Using the questionnaire scale "Intentions for Future Use" How much each participant intends to use the products in the future. Scale: "Think about the product you just used. If this was the only flavor available, how likely would you be to try this flavor again? 1. Extremely unlikely 2. Unlikely 3. Neutral 4. Likely 5. Extremely likely The range of observed responses from participants for both groups was 1-5. Not all participants completed all study measures so the number of respondents is lower than enrolled.

Secondary Outcome Measures

Name	Time	Method
Questionnaire Scale "Perceptions of Flavor"	during the intervention	On a scale from 0 to 100 where 0 is not at all and 100 is extremely, to what extent did you like the flavor you just used? The observed range of responses from participants in both arms was from 0 to 100. Not all participants completed all study measures so the number of respondents is lower than enrolled.
Questionnaire Scale "Product Demand"	during the intervention	On a scale from 0 to 100 where 0 is not at all and 100 is extremely, how willing would you be to use the flavor you just used again in the future? The observed range of responses from participants in both arms was from 0 to 100. Not all participants completed all study measures so the number of respondents is lower than enrolled.
Questionnaire Scale "Subjective Vaping Experience"	during the intervention	Please indicate how you are feeling right now on a scale from 0 to 100 where 0 is not at all and 100 is extremely. How pleasant would the e-cigarette be to use right now? The observed range of responses from participants for both arms was 0 to 100. Not all participants completed all study measures so the number of respondents is lower than enrolled.