Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease

Terminated

• Conditions: Aortic Valve Stenosis

• Registration Number: NCT01939678
• Lead Sponsor: Region Örebro County

Brief Summary

The purpose of this study is to investigate whether mutations in genes coding for Na/Pi-cotransporters are associated with aortic valve calcification. A patient population with premature aortic valve calcification treated with aortic valve replacement will be screened for mutations in these specific genes. Furthermore, aortic valve tissue received from the operations, will be examined for the presence of Na/Pi-cotransporters, and for molecular characterization of the transporters.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-08-27
• Study Start: 2013-09
• Study First Submitted QC: 2013-09-05
• Study First Posted: 2013-09-11
• Status Verified: 2019-09
• Primary Completion: 2019-09
• Study Completion: 2019-09
• Last Update Submitted: 2019-09-09
• Last Update Posted: 2019-09-11

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

• Patients with aortic valve calcification that will be treated with an aortic valve replacement.
• Age ≤ 65 years.
• Signed and dated informed consent.

Exclusion Criteria

• Inability to provide informed consent
• Earlier radiation therapy of the thorax
• Severe renal disease (patients in treatment with dialysis)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mutations in sodium-phosphate cotransporters in patients with calcific aortic valve disease	At the time of aortic valve replacement	Mutations in genes coding for Na/Pi-cotransporters

Trial Locations

Locations (1)

Department of Cardiology, Orebro University Hospital; 🇸🇪 Orebro, Sweden