Investigation on the Hesitancy of COVID-19 Vaccination Among Liver Transplant Recipients in China

Completed

• Conditions: Vaccine Hesitancy
• Interventions: Other: Perceptions and attitudes towards COVID-19 and COVID-19 vaccine

• Registration Number: NCT05532592
• Lead Sponsor: RenJi Hospital

Brief Summary

On WeChat platform, through a point-to-point connection, and carry on the questionnaire survey to collect information of liver transplant recipients followed-up by the department of Liver Surgery, Renji Hospital Shanghai Jiao Tong University. Patients meeting inclusion and exclusion criteria will be selected. Conduct statistical analysis to describe the incidence of adverse reactions related to COVID-19 vaccine after liver transplantation, and to compare and evaluate the factors leading to COVID-19 vaccine hesitancy.

Detailed Description

On WeChat platform, through a point-to-point connection, and carry on the questionnaire survey to collect information of liver transplant recipients followed-up by the department of Liver Surgery, Renji Hospital Shanghai Jiao Tong University. Questionnaire items including demographic characteristics, understanding of COVID-19, attitude toward COVID-19 vaccine. Patients meeting inclusion and exclusion criteria will be selected. Conduct statistical analysis to describe the incidence of adverse reactions related to COVID-19 vaccine after liver transplantation, and to compare and evaluate the factors leading to COVID-19 vaccine hesitancy.

Study Timeline

• Study Start: 2022-04-27
• Primary Completion: 2022-05-10
• Study Completion: 2022-05-30
• Status Verified: 2022-09
• Study First Submitted: 2022-09-05
• Study First Submitted QC: 2022-09-07
• Last Update Submitted: 2022-09-07
• Study First Posted: 2022-09-08
• Last Update Posted: 2022-09-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 449

Inclusion Criteria

1. age ≥ 18
2. recipients after liver transplantation surgery

Exclusion Criteria

1. Incomplete data (missing questionnaire information), such as lack of age, gender, indication for transplantation, time after transplantation and other indicators
2. loss to follow-up
3. COVID-19 vaccination before liver transplantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
hesitancy group (HG)	Perceptions and attitudes towards COVID-19 and COVID-19 vaccine	Participants who were uncertain or refused to be vaccinated.
no hesitancy group (NHG)	Perceptions and attitudes towards COVID-19 and COVID-19 vaccine	Participants who got vaccine after transplantation or were willing to be vaccinated.

Primary Outcome Measures

Name	Time	Method
Number of Participants with COVID-19 Vaccine Hesitancy	through study completion, an average of 1 year	In the questionnaire, participants who expressed hesitancy or explicitly refused to receive the COVID-19 vaccine were considered vaccine hesitancy.

Trial Locations

Locations (1)

The department of Liver Surgery, Renji Hospital Shanghai Jiao Tong University.; 🇨🇳 Shanghai, Shanghai, China