Can minocycline reverse morphine-induced respiratory depression in obstructive sleep apnea patients?- A pilot study
Phase 1
Recruiting
- Conditions
- obstructive sleep apneaRespiratory - Sleep apnoea
- Registration Number
- ACTRN12610001074088
- Lead Sponsor
- HMRC Training Fellowship
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 10
Inclusion Criteria
Aged between 18-60 years who have previously been tested by a polysomnography (PSG) study that shows they have sleep apnoea, with Apnea Hypopnea Index >15/hr and SpO2 nadir 90-70%.
Exclusion Criteria
1. History of adverse effects from opioids or minocycline. 2. History of drug abuse. 3. Regular use of opiates. 4. Current or recent severe physiological or psychological illness including severe cardiovascular (hypertension) or CNS diseases. 5. Presence of another severe sleep disorders (such as period limb movement disorders or shift work sleep disorder). 6. Concurrent using CPAP or taking of other medications which might interfere with the study drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SpO2 (Oxygen Saturation) nadir during sleep[at two cross-over polysomnography (PSG) nights and at screening (baseline) PSG night];%Total sleep time SpO2 <90% during sleep. The parameter is part of the PSG measurement.[at two cross-over PSG nights and at screening (baseline) PSG night];Central chemosensitivity tested by ventilatory chemoreflex tesing system[at two cross-over PSG evenings during awake and at screening (baseline) examination]
- Secondary Outcome Measures
Name Time Method Oxygen desaturation index (ODI) as part of PSG assessment[at two cross-over PSG nights and at screening (baseline) PSG night];CO2 recruitment threshold tested by chemoreflex testing system[at two cross-over PSG evenings during awake and at screening (baseline) examination];Pain threshold (Mechanical Detection Threshold) tested by Von Frey Hair[at two cross-over PSG evenings during awake]