Examination of Association Between Glucose, Lipid Metabolism and Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- postprandial metabolic markers including glucose, cholesterol, triglyceride, ghrelin, leptin
研究概览
简要总结
The purpose of this study is to examine postprandial glucose and lipid metabolism in patients with obstructive sleep apnea.
详细描述
Obstructive sleep apnea (OSA) is an increasingly prevalent condition that is characterized by repetitive upper airway obstructions. OSA has been independently associated with insulin resistance, suggesting that OSA may contribute to the development of type 2 diabetes and the metabolic syndrome. Recently, postprandial glucose and lipid have been reported as excellent predictors for mortality and cardiovascular risk. However, the association between postprandial glucose, lipid metabolism and OSA are not clear. In addition, humoral factors such as ghrelin and leptin are associated with obesity and OSA, but postprandial changes of which in patients with OSA are not well known. The aim of present study is to examine postprandial glucose and lipid metabolism, humoral factors in OSA before and after 3 months of continuous positive airway pressure (CPAP) treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects on admission for sleep study under the Respiratory Care and Sleep Control Medicine, Kyoto University Hospital.
- •Subjects diagnosed with OSA (apnea hypopnea index >=5/hour) by overnight polysomnography.
排除标准
- •Subjects treating for acute infections or malignancy.
- •Subjects with severe anemia, diabetes,and renal failure.
结局指标
主要结局
postprandial metabolic markers including glucose, cholesterol, triglyceride, ghrelin, leptin
时间窗: baseline and 3 months after CPAP
次要结局
- respiratory events (ie. apnea-hypopnea index)(baseline and 3 months after CPAP)
- inflammatory biomarkers (ie. IL-6, CRP)(baseline and 3 months after CPAP)
- quality of life(baseline and 3 months after CPAP)
- sleep quality(baseline and 3 months after CPAP)
- sympathetic activity in urine(baseline and 3 months after CPAP)
- appetite(baseline and 3 months after CPAP)
- endothelial function(baseline and 3months after CPAP)
研究者
Toru Oga
Medical doctor
Kyoto University, Graduate School of Medicine