The renin-angiotensin-aldosterone (RAAS) axis, endothelial function and hypertension: diagnostic strategies, and therapeutic role of potassium supplementatio
Not Applicable
Completed
- Conditions
- Hypertension, cardiovascular risk, hyperaldosteronismCirculatory System
- Registration Number
- ISRCTN55798944
- Lead Sponsor
- Royal Victoria Hospital (UK)
- Brief Summary
2014 results in https://pubmed.ncbi.nlm.nih.gov/24048291/ (added 30/12/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Study 1:
1.1. Patients (both males and females) aged 40-70 with moderate (>10%) cardiovascular disease risk (Joint British Societies' [JSB2] guidelines)
Study 2:
Three groups of participants (both males and females, all within age 18-70):
2.1. Patients with essential hypertension
2.2. Patients with hyperaldosteronism
2.3. Healthy volunteers
Exclusion Criteria
Study 1:
1.1. A history or renal or cardiovascular disease
1.2. Fasting glucose >7 mmol/l
1.3. Serum potassium >5.5 mmol/l
1.4. Treated seated blood pressure >140/90 mmHg
1.5. Women on hormone replacement therapy (HRT)
1.6. Pregnancy
Study 2:
2.1. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method