TCTR20240708002已完成不适用
Antibody Response in People living with HIV Comparing CD4 T-cell Levels more than 200 vs. lower or equal 200 cells/mm3 after mRNA COVID-19 Vaccine Booster
Thai AIDS society0 个研究点目标入组 74 人开始时间: 2024年7月8日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 74
研究概览
简要总结
In low CD4 group, participants exhibited lower baseline levels of both Anti RBD Ig and sVNT against all variants. In post-booster vaccination with the bivalent COVID-19 vaccine, the lower CD4 group also showed reduced immunogenicity. Higher GMR was observed in low CD4 group
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 N/A (No limit)（—）
- 性别
- All
入选标准
- •1. Individuals living with HIV aged 18 years and above
- •2. on stable antiretroviral regimen for at least three months
- •3. Received at least two doses of the primary COVID-19 vaccine more than three months prior to enrollment in the study
排除标准
- •1. virologic failure, defined as an HIV viral load exceeding 200 copies/mL
- •2. high-level immunosuppression, such as the use of prednisolone at doses exceeding 20 mg/day
- •methotrexate at doses exceeding 0.4 mg/kg/week, or previous administration of rituximab or TNF-alpha blockers within the past year
- •3. active autoimmune disease
- •4. contraindications for COVID-19 vaccination
- •5. previous administration of monoclonal antibodies, JAK inhibitors, or convalescent plasma for COVID-19
- •6. receipt of any other vaccination within 15 days prior to enrollment
- •7. self-reported history of SARS-CoV-2 infection in the 3 months prior to enrollment.
研究者
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