Evaluation of Late Treatment Effects in Long-Term Survivors of Hodgkin's Disease Previously Treated at NIH: A Multi-Institutional Trial

Background:

• Researchers are greatly interested in knowing more about the long-term effects of various treatments for cancers such as Hodgkin's disease, particularly from those who have lived 20 to 30 years after treatment.
• Patients who were treated at the National Institutes of Health (NIH) may have undergone different treatments for which more long-term information is needed.

Objectives:

• To examine the body systems of long-term survivors of Hodgkin's disease to see if there are any long- term consequences of treatment for Hodgkin's disease.
• To learn more about the long-term effects of cancer treatments.

Eligibility:

• Survivors of Hodgkin's disease who were previously treated at the NIH.
• Participants must be at least 18 years of age.

Design:

• Participants will need to sign consent forms to allow researchers to obtain documentation of medical history, including prior treatment for Hodgkin's disease and prior NIH treatment, including protocol number, where applicable:
• Pertinent medical records, pathology reports, and radiographic imaging studies will be reviewed.
• Primary care physician's name, address, and other contact information are also required.
• Evaluations during the assessment period:
• Complete physical examination.
• Laboratory studies of blood, urine, and stool samples.
• Radiologic evaluations, including computerized tomography (CT) and magnetic resonance imaging (MRI) scans for all participants and mammograms for females.
• Cardiac evaluation, vascular studies, and pulmonary studies to measure heart and lung function, and digestive tests to measure stomach and intestinal function.
• Neurocognitive testing to measure brain function.
• Optional skin biopsy.
• Participants will be asked to complete questionnaires assessing current quality of life and daily living skills.