To study effect of bolus high osmolarity IV fluids (colloid) on pulse, blood pressure when given before and after tourniquet release in total knee replacements.
Phase 1
- Conditions
- Health Condition 1: M179- Osteoarthritis of knee, unspecified
- Registration Number
- CTRI/2019/01/016838
- Lead Sponsor
- Self
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
18-65 yr
ASA grade I and II
Elective Total knee arthroplasty patients
Under Spinal anesthesia
Exclusion Criteria
Emergency surgery
Long standing Diabetes cases or on insulin.
Hypertensive patients on more than one antihypertensive drugs or on diuretics, or on beta blocker, or alfa2 agonists.
Altered coagulation profile, or on antiplatelet drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Impact of tourniquet release on immediate hemodynamic stability. <br/ ><br>2. Effectiveness of pre-loading and co-loading in attenuating hemodynamic variation <br/ ><br>Timepoint: 30 minutes after tourniquet release
- Secondary Outcome Measures
Name Time Method 1.Effect of preloading on baseline vitals. <br/ ><br>2. Effect of tourniquet inflation on hemodynamicsTimepoint: till end of surgery