An Exploratory Self-Controlled Study on the Preventive Effect of the Simple Surgical Glove Compression Technique Against Chemotherapy-Induced Peripheral Neuropathy

简要总结

主要结局

次要结局

• Incidence of CIPN as determined by changes in tactile sensitivity assessed with the Semmes-Weinstein monofilament test(From baseline to the end of and 6 months after completion of neoadjuvant chemotherapy)
• Incidence of CIPN according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0(From baseline to the end of and 6 months after completion of neoadjuvant chemotherapy)
• Change in scores and the sum score of four hand-related items of the FACT/GOG-Ntx subscale (range: -16to+16; higher scores indicate better neurotoxicity-related quality of life).(From baseline (prior to neoadjuvant chemotherapy) to after 8 weeks of neoadjuvant chemotherapy in breast cancer)
• The overall change in the FACT/GOG-Ntx subscale score (range: -44to44; higher scores indicate better neurotoxicity-related quality of life)(From baseline to the end of neoadjuvant chemotherapy and 6 months after completion of neoadjuvant chemotherapy)
• Changes in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) scores (range: -12to12, higher scores on functional and global health domains indicate better quality of life,; -84to84; while higher(At baseline (prior to initiation of neoadjuvant chemotherapy), at 8 weeks of neoadjuvant chemotherapy, at 2 weeks after completion of neoadjuvant chemotherapy, and at 6 months after completion of neoadjuvant chemotherapy.)
• Changes in the maximum width and height of the lunula of each finger(At baseline (prior to initiation of neoadjuvant chemotherapy), at 8 weeks of neoadjuvant chemotherapy, at 2 weeks after completion of neoadjuvant chemotherapy, and at 6 months after completion of neoadjuvant chemotherapy.)