Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma

Phase 2

Completed

• Conditions: Melasma
• Interventions: Drug: Metformin and Nicotinamide vs Kligman Formula

• Registration Number: NCT05790577
• Lead Sponsor: Ishtiaq Ahmed

Brief Summary

Comparison of 30% Metformin and 2% Nicotinamide lotion with kligman formula in the treatment of Melasma

Detailed Description

A comparative study to evaluate Efficacy and tolerability of new lotion in the treatment of Melasma.

Study Timeline

• Study Start: 2022-02-01
• Study First Submitted: 2022-08-06
• Primary Completion: 2023-02-15
• Study Completion: 2023-02-15
• Study First Submitted QC: 2023-03-16
• Study First Posted: 2023-03-30
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-22
• Last Update Posted: 2023-05-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• Age between 18-50
• No systemic therapy
• All Co-morbids

Exclusion Criteria

• Pregnancy
• Age >50
• Taking oral treatment for melasma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Metformin 30% and 2% Nicotinamispde	Metformin and Nicotinamide vs Kligman Formula	Metformin 30% plus Nicotinamide 2% in the reatment of Melasma
Kligman formula	Metformin and Nicotinamide vs Kligman Formula	Kligman formula in the treatment of Melasma

Primary Outcome Measures

Name	Time	Method
Comparison of 30% Metformin and 2% Nicotinamide lotion with kligman formula in the treatment of Melasma	12 weeks	Efficacy with measurement of MASI score 4 weeks apart

Trial Locations

Locations (1)

PakEmiratesMH; 🇵🇰 Rawalpindi, Punjab, Pakistan