Noninvasive Brain Stimulation to Treat Core Social Deficits in Autism Spectrum Disorder
概览
- 阶段
- 不适用
- 干预措施
- Transcranial Magnetic Stimulation (TMS)
- 疾病 / 适应症
- Autism Spectrum Disorder
- 发起方
- Yale University
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- right hemisphere N170 latency
- 状态
- 招募中
- 最后更新
- 2个月前
概览
简要总结
This is a randomized interventional study designed to evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in adults with autism spectrum disorder (ASD).
详细描述
The primary objective of this study is to determine whether rTMS increases the brain response to faces in a population of adults with ASD. This study will assess critical aspects of social cognition using the electroencephalogram (EEG), event-related potentials (ERPS), and eye-tracking (ET) prior to and following a single rTMS session (or Sham) to provide preliminary insight into the potential of rTMS as a tool to modify social brain function in this population. Participant visits will include a baseline assessment of neuropsychological, cognitive and behavioral function, and a pre and post TMS session with EEG (electroencephalogram) and eye-tracking to measure neural and visual attentional social response. Two study visits will be scheduled for each participant lasting approximately 4-5hrs total.
研究者
入排标准
入选标准
- •Individuals between the ages of 18 and 40 years old with typical development or with a diagnosis of autism spectrum disorder.
- •Individuals able to participate in an EEG and eye-tracking experiment.
排除标准
- •Participants reporting significant head trauma or serious brain illness.
- •Participants with major psychiatric illness that would preclude completion of study measures.
- •Participants with a history of serious medical illness, stroke, seizures, epileptiform EEG abnormalities, or family history of seizures.
- •Participants taking prescription medications that may affect cognitive processes under study.
- •Participants who have taken alcohol or recreational drugs within the preceding 24 hours.
- •Females of known/suspected pregnancy or who test positive on a pregnancy test.
- •Participants with a history of metalworking or injury by shrapnel or metallic objects are also excluded.
- •Participants with a history of prior TMS therapy or use of an investigational drug within 12 weeks of visit.
- •Participants with an IQ (intelligence quotient) below 80.
研究组 & 干预措施
Transcranial Magnetic Stimulation - real
Participants will receive active TMS during their study visit
干预措施: Transcranial Magnetic Stimulation (TMS)
Transcranial Magnetic Stimulation - sham
Participants will receive sham stimulation during their study visit simulating TMS
干预措施: Transcranial Magnetic Stimulation (TMS)
结局指标
主要结局
right hemisphere N170 latency
时间窗: Measures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours
EEG brain response to faces as measured by the N170 component in milliseconds
proportion of visual attention to the eye region of the face
时间窗: Measures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours
visual attention to the eye region of the face as measured by eye tracking in seconds