Impact of LVAD Implantation on Micro- and Macrovascular Function
- Conditions
- End Stage Heart Failure
- Registration Number
- NCT02174133
- Lead Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
- Brief Summary
End stage heart failure is characterized by a critical inability of the heart to meet the organism's blood demand even under resting conditions. Heart transplantation (HTx) is the established therapeutic approach in the treatment of end stage heart failure and still the gold standard treatment. Left ventricular assist devices (LVADs) are considered as a vital therapeutic option to temporarily or permanently assist the failing circulation. The hemodynamic vascular consequences of implanting LVADs have not been studied in detail. The aim of the study is to investigate the effect of LVAD implantation compared to heart transplant (HTx) on micro- and macrovascular function in patients with end stage heart failure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- patients after HTX
- patients after LVAD implantation
- patients with stable coronary heart disease and normal systolic left ventricular function
- healthy volunteers
- written informed consent
- acute inflammation
- cardiac arrhythmia
- renal failure
- malignant disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Macrovascular function measured by flow-mediated vasodilation (FMD) 3 months after implantation
- Secondary Outcome Measures
Name Time Method microparticles determined by Flow Cytometry 3 months after implantation Microvascular function assessed by non-invasive laser Doppler imaging 3 months after implantation
Trial Locations
- Locations (1)
Division of Cardiology, Pulmonology and Vascular Medicine Duesseldorf,
🇩🇪Duesseldorf, Germany