Impact of LVAD Implantation on Micro- and Macrovascular Function
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- End Stage Heart Failure
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Macrovascular function measured by flow-mediated vasodilation (FMD)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
End stage heart failure is characterized by a critical inability of the heart to meet the organism's blood demand even under resting conditions. Heart transplantation (HTx) is the established therapeutic approach in the treatment of end stage heart failure and still the gold standard treatment. Left ventricular assist devices (LVADs) are considered as a vital therapeutic option to temporarily or permanently assist the failing circulation. The hemodynamic vascular consequences of implanting LVADs have not been studied in detail. The aim of the study is to investigate the effect of LVAD implantation compared to heart transplant (HTx) on micro- and macrovascular function in patients with end stage heart failure.
Investigators
Klinik für Kardiologie, Pneumologie und Angiologie
Division of Cardiology, Pulmonary Diseases, Vascular Medicine
Heinrich-Heine University, Duesseldorf
Eligibility Criteria
Inclusion Criteria
- •patients after HTX
- •patients after LVAD implantation
- •patients with stable coronary heart disease and normal systolic left ventricular function
- •healthy volunteers
- •written informed consent
Exclusion Criteria
- •acute inflammation
- •cardiac arrhythmia
- •renal failure
- •malignant disease
Outcomes
Primary Outcomes
Macrovascular function measured by flow-mediated vasodilation (FMD)
Time Frame: 3 months after implantation
Secondary Outcomes
- microparticles determined by Flow Cytometry(3 months after implantation)
- Microvascular function assessed by non-invasive laser Doppler imaging(3 months after implantation)