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Clinical Trials/NCT01696708
NCT01696708CompletedNot Applicable

Study of the Brain Energy Profile Evolution, Using 31Phosphorus-Nuclear Magnetic Resonance Spectroscopy, at Different Stages of Huntington Disease

Institut National de la Santé Et de la Recherche Médicale, France1 site in 1 country50 target enrollmentStarted: December 6, 2012Last updated:
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Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
50
Locations
1
Primary Endpoint
Ratio of Inorganic Phosphate (Pi) over phosphocreatine (PCr): Pi/PCr
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The purpose of this project is to study brain energy profile evolution at different stages of the Huntington disease.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Parallel
Primary Purpose
Basic Science
Masking
None

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •UHDRS < 50
  • •Age > 18 years
  • •Ability to undergo MR scanning
  • •Covered by french social security

Exclusion Criteria

  • •Evidence of psychiatric disorder
  • •Attendant neurological disorder
  • •Contraindications to MRI (claustrophobia, metallic or material implants)
  • •Severe head injury
  • •Unable to understand the protocol
  • •Pregnancy
  • •Failure to give informed consent
  • •Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent)
  • •Unwillingness to be informed in case of abnormal MRI

Arms & Interventions

Patients

Other

31-Phosphorus RMN Spectroscopy

Intervention: 31-Phosphorus RMN Spectroscopy (Other)

Volunteers

Other

31-Phosphorus RMN Spectroscopy

Intervention: 31-Phosphorus RMN Spectroscopy (Other)

Outcomes

Primary Outcomes

Ratio of Inorganic Phosphate (Pi) over phosphocreatine (PCr): Pi/PCr

Time Frame: 2 years

31P-MRS allows quantification of high-energy phosphate metabolites such as phosphocreatine and inorganic phosphate

Secondary Outcomes

  • Correlation between primary outcome measure and clinical parameters(2 years)
  • Study of longitudinal changes in Pi/PCr ratio over time.(2 years)

Investigators

Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Sponsor Class
Other Gov
Responsible Party
Sponsor

Study Sites (1)

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