The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 315
- 试验地点
- 1
- 主要终点
- QTc interval
研究概览
简要总结
The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval. Changes in the flow of ion currents could result from the genetic variation of myocardial ion channels by gene polymorphism. This study is to investigate the association of cardiac ion channel related gene polymorphism and prolonged QTc interval after endotracheal intubation in adult patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20-65 years old
- •scheduled for general anesthesia requiring direct laryngoscopy
排除标准
- •Patients taking antihypertensive medication (beta-blocker, CCB)
- •patients taking other medications known to affect QTc interval
- •Patients with abnormal ECG and prolonged QTc (>500 msec)
- •Diabetes, liver disease, kidney disease, heart failure, congenital heart disease
- •Severe electrolyte imbalance
- •illiterate, foreigners who cannot understand the consent form
结局指标
主要结局
QTc interval
时间窗: Before anesthesia, Before laryngoscopy, Right after laryngoscopy, 5 minutes after laryngoscopy
QTc interval prolongs followed by laryngoscopy due to changes in the autonomic nervous system. The restoration of the prolonged QTc could also be affected by the balance of autonomic nervous system or changes in the related cardiac ion channels.
次要结局
未报告次要终点