NL-OMON50737招募中2 期
ongitudinal imaging of tau accumulation in the preclinical stages of AD - LUNAR
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Clinically diagnosed with 'subjective cognitive decline' after the
- •standardized dementia screening performed at the VUmc Alzheimer Center
- •- At least 50 years of age
- •- Enrollment in the FIAD cohort (protocol nr 13-256)
- •- Have received or will receive a [18F]Florbetapir PET scan 90 days before or
- •after the [18F]AV-1451 PET scan
排除标准
- •- Has contraindications for MRI scanning and therefore has not received brain
- •- Has evidence for structural abnormalities such as major stroke or mass on MRI
- •that is likely to interfere with interpretation of PET scan
- •- Is a woman of childbearing potential who is not surgically sterile, not
- •refraining from sexual activity or not using reliable methods for
- •contraception. Women of childbearing potential must not be pregnant or breast
- •feeding at screening.
- •- Has a relevant history of severe drug allergy or hypersensitivity. Relevant
- •severe drug allergies should be determined by the Principal Investigator or
- •Co-Prinicipal Investigator, and any questions about a subject's eligibility can
- •be directed to Avid Radiopharmaceuticals Inc.;
- •- Has ever participated in an experimental study with a tau or amyloid
- •targeting agent, unless it can be documented that the subject received only
- •placebo during the course of the trial;
- •- Has been injected with a previously administered radiopharmaceutical within 6
- •terminal half-lives OR when total yearly radiation exposure exceeds 10 mSv
- •- Has a history of severe traumatic brain injury (TBI)
研究者
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