Narrow Band Imaging Bronchoscopy During SARS-CoV2 Infection

Active, not recruiting

• Conditions: Narrow-band Imaging; Bronchoscopy; Covid19
• Interventions: Other: NBI images and/or videos

• Registration Number: NCT04884061
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Vascular modifications have been described during SARS-CoV2 infection, especially a dilatation of the bronchial arteries. Within the airway wall, small branches of the bronchial arteries cross the muscle layer to develop a submucosal network. The Narrow Band Imaging technique is used during bronchoscopy to achieve a maximum contrast of vessels and the surrounding mucosa. Therefore, it enables to observe the microvessel structure and its distribution in the bronchial mucosa. The aim of this study is to describe the vasculature pattern of the bronchial tree during infection with SARS-CoV2.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-07
• Study First Submitted: 2021-05-07
• Study First Submitted QC: 2021-05-11
• Study First Posted: 2021-05-12
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-09
• Last Update Posted: 2023-02-10
• Primary Completion: 2023-07
• Study Completion: 2023-07

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• Patients who undergo bronchoscopy with image and/or videos recording of NBI aspect of the proximal bronchial tree (carina, right and left upper lobe).
• Patients hospitalized with SARS-CoV2 infection proven by RT-PCR test
• patients hospitalized with lower respiratory tract infections unrelated to SARS-CoV2 (RT-PCR negative for SARS-CoV2)
• Patients who have had bronchoscopy performed as part of the assessment of a distal pulmonary nodule (RT-PCR negative for SARS-CoV2).

Exclusion Criteria

• Patients under legal protection
• Patients who refuses the use of his personal medical data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Experimental	NBI images and/or videos	Patients hospitalized with SARS-CoV2 infection proven by RT-PCR test
Comparator 2	NBI images and/or videos	Patients who have had bronchoscopy performed as part of the assessment of a distal pulmonary nodule (RT-PCR negative for SARS-CoV2).
Comparator	NBI images and/or videos	Patients hospitalized with lower respiratory tract infections unrelated to SARS-CoV2 (RT-PCR negative for SARS-CoV2)

Primary Outcome Measures

Name	Time	Method
Variation of the vasculature pattern of the bronchial mucosa between the three patient groups	2 months

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France