The Asymmetry of Endometriotic Lesions as Demonstration of the Theory of Menstrual Reflux and Anatomical Niches: Italian Multicenter Study by the ETIC Group
Overview
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 2,000
- Locations
- 1
- Primary Endpoint
- Asymmetric distribution of endometriotic lesions on paired pelvic organs
Overview
Brief Summary
This study aims to understand whether endometriosis lesions - and tumors that can arise in association with endometriosis - occur more often on one side of the pelvis than the other.
During surgery, doctors will record the exact location of each lesion to see if there is a consistent right- or left-sided pattern.
Understanding these patterns may help improve knowledge about how endometriosis develops (pathogenesis), and thus improve its treatment.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age ≥18 years at the time of histological diagnosis of endometriosis
- •patients undergoing surgery with endometriotic lesions or patients with endometriotic lesions associated with endometrioid or clear cell ovarian cancer (Stage I-II) or borderline seromucinous ovarian cancer
- •first operation for endometriosis in the reference center (if recurrence consider only if both operations were performed at the reference center).
Exclusion Criteria
- •age \<18 years
- •patients affected by Stage I-II endometrioid or clear cell carcinoma or seromucinous borderline ovarian cancer not associated with endometriosis or in a more advanced stage of disease
- •women with an ultrasound diagnosis of endometriosis who have not undergone surgery
- •previous operations for endometriosis performed at another center
Outcomes
Primary Outcomes
Asymmetric distribution of endometriotic lesions on paired pelvic organs
Time Frame: At the time of index surgery
Proportion of patients presenting an asymmetric (right- or left-sided) distribution of endometriotic lesions on even and symmetrical pelvic organs (e.g., ovaries, uterosacral ligaments), based on the laterality observed and described during the index surgical procedure. Side-specific frequencies (right vs left) will be reported as number and percentage.
Secondary Outcomes
- Asymmetric distribution of malignant ovarian lesions related to endometriosis(At the time of index surgery)