The prevalence of growth hormone deficiency in autoimmune thyroid disease

Completed

• Conditions: Autoimmune hypothyroidism; Nutritional, Metabolic, Endocrine; Disorders of thyroid gland

• Registration Number: ISRCTN57632130
• Lead Sponsor: Academic Medical Center (AMC) (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-11-22
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

1. Autoimmune hypothyroidism
2. Adequate thyroxine treatment
3. Aged between 20 and 70 years old, both men and women

Exclusion Criteria

1. History of hypothalamic or pituitary disease or known growth hormone deficiency
2. Pregnancy
3. Hypothyroidism after treatment for Graves' disease or surgery or radioactive iodine (I131)
4. Major concurrent diseases
5. Use of medications known to interfere with the growth hormone-Insulin-like Growth Factor-I (IGF-1) axis
6. No informed consent
7. Alcohol or drug abuse

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of growth hormone deficiency in patients with autoimmune hypothyroidism, measured a the first visit and when the second test is necessary at a second visit that is planned a few weeks later.

Secondary Outcome Measures

Name	Time	Method
Quality of life in patients with autoimmune hypothyroidism with or without growth hormone deficiency.