Ovulation induction in women with newly diagnosed polycystic ovary syndrome: a randomised double blind clinical trial comparing clomiphene citrate plus metformin with clomiphene citrate plus placebo

Completed

• Conditions: Polycystic Ovary Syndrome (PCOS); Nutritional, Metabolic, Endocrine; Ovarian dysfunction

• Registration Number: ISRCTN55906981
• Lead Sponsor: Academic Medical Center (AMC) (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 228

Inclusion Criteria

All patients with chronic anovulation World Health Organization (WHO) type II, polycystic ovaries diagnosed by transvaginal ultrasonography and child wish.

Exclusion Criteria

1. Other causes of anovulation
2. Age over 40 years and liver, kidney or heart disease/failure (i.e. abnormal results on liver function tests
3. Serum creatinine concentration greater than 95 umol/l or a history of heart disease/failure)
4. Sperm quality indicating male factor subfertility (total motile count less than 10 x 10^6)

Study & Design

• Study Type: Interventional
• Study Design: Not specified