ACTRN12608000307303已完成3 期
A randomised, controlled comparison of uridine, pravastatin or uridine plus pravastatin to accelerate recovery of lipoatrophy in Human immunodeficiency virus (HIV)-infected adults
St Vincent's Hospital , Sydney0 个研究点目标入组 40 人开始时间: 2008年6月30日最近更新:
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. subcutaneous lipoatrophy in at least 2 body sites, at least one of which is moderate or severe according to both the patient and the doctor
- •2. HIV viral load <50 copies /ml plasma for at least 3 months
- •3. use of stable HARRT not including tNRTI for at least 3 months
- •4. no grade 3or 4 laboratory values at baseline
排除标准
- •1. zidovudine (AZT) or stavudine (d4T) in preceding 12 weeks (12/52)
- •2. ongoing opportunistic infection , other AIDS -defining illness or other illness that would interfere with participation
- •3. clinically significant renal or hepatic disease
- •4.lipid levels necessitating statin treatment
- •5. anabolic steriods, growth hormone, or supra-physiological corticosteriod doeses.
- •6. pregnancy or breast feeding
- •7. allergy to any component of the randomised drugs
- •8. prior use of uridine
研究者
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