Cortical Activation in Individuals With Finger Amputation During Mirror Versus Imagery Treatment

Not Applicable

• Conditions: Amputees
• Interventions: Other: Mirror; Other: Imagery

• Registration Number: NCT02838485
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

Goals : ( a) to examine differences in cortical activity during hand movements with a mirror compared to imagery of the same movements, and (b) to examine correlation between cortical activity during imagery or mirror treatment and the pain and performance measures in finger amputees.

A cross-sectional study of 20 subjects in a Functional Magnetic Resonance Imaging (fMRI) preforming mirror therapy hand movement and imagery hand movement. Also, Visual Analogue Scale for pain and the Disability of the Arm, Shoulder and Hand (DASH) questionnaire and Jebsen Taylor Hand Function Test will be used.

Detailed Description

Goals : ( a) to examine differences in cortical activity during hand movements with a mirror compared to imagery of the same movements, and (b) to examine correlation between cortical activity during imagery or mirror treatment and the pain and performance measures in finger amputees.

A cross-sectional one-meeting study of 20 subjects (finger amputees) in a Functional Magnetic Resonance Imaging (fMRI) preforming mirror therapy hand movement and imagery hand movement. Also, Visual Analogue Scale for pain and the Disability of the Arm, Shoulder and Hand (DASH) questionnaire and Jebsen Taylor Hand Function Test will be used.

Study Timeline

• Status Verified: 2016-07
• Study First Submitted: 2016-07-17
• Study First Submitted QC: 2016-07-17
• Last Update Submitted: 2016-07-17
• Study First Posted: 2016-07-20
• Last Update Posted: 2016-07-20
• Study Start: 2016-08
• Primary Completion: 2017-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Following unilateral traumatic finger or fingers amputation (1 to 3 fingers)
• Self-reported limited functionality, sensory disorder or pain

Exclusion Criteria

• Are not comparable with MRI restrictions
• Chronic pain disease
• Psychiatric condition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Amputees	Mirror	The subjects will receive both mirror and imagery treatments in a cross-over design.
Amputees	Imagery	The subjects will receive both mirror and imagery treatments in a cross-over design.

Primary Outcome Measures

Name	Time	Method
Cortical activity	1 hour	Activation of supplementary motor area (SMA), S1 and M1.

Secondary Outcome Measures

Name	Time	Method
Visual analogue scale	10 minutes	Filled by the subject for subjective pain in residuum discomfort.
The Jebsen Taylor Hand Function Test	30 minutes	Standard evaluation of hands functionality.
Disability of the Arm, Shoulder and Hand	30 minutes	Questionnaire regarding the disability and daily activities difficulties.

Trial Locations

Locations (1)

Hadassah Medical Center; 🇮🇱 Jerusalem, Israel