Identification of Corticomedullary Differentiation Along Different Stage of Pregnancy

• Conditions: Nephropathy

• Registration Number: NCT02193516
• Lead Sponsor: Meir Medical Center

Brief Summary

Corticomedullary differentiation (CMD) abnormality (absent/reversed) is a parameter that can indicate possible nephropathy. The evolution of CMD across gestation had not been well established. Devrendt et al demonstrated the presence of CMD in all fetuses older then 20 weeks. In our study we would like to determine the exact timing of it's sonographic visualisation. This is a prospective study recruiting women between 14-24 week gestation during routine ultrasound screening. A midsagittal image of each kidney will be taken by a single sonographer and examined for the presence of the CMD by two other sonographers blinded to gestational age.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-06-29
• Status Verified: 2014-07
• Study Start: 2014-07
• Study First Submitted QC: 2014-07-15
• Last Update Submitted: 2014-07-15
• Study First Posted: 2014-07-17
• Last Update Posted: 2014-07-17
• Primary Completion: 2015-06
• Study Completion: 2015-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 330

Inclusion Criteria

• pregnant women 14-24 weeks
• singleton pregnancy
• Appropriate for gestational age fetuses
• well dated pregnancy

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Exclusion Criteria

• family history of renal disease
• small /large for gestational age fetuses
• known structural anomalies
• unknown dating

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CMD presence	A single exam for each participent. The photos will be reviewed within up to 6 month from examination date

Trial Locations

Locations (1)

Meir Hospital; 🇮🇱 kfar Sava, Israel