Intravenous Artesunate and Malaria

Phase 4

• Conditions: Malaria
• Interventions: Drug: artesunate; Drug: Quinine

• Registration Number: NCT01805232
• Lead Sponsor: University of Khartoum

Brief Summary

Intravenous artesunate is egual to quinine in the treatment of severe malaria

Detailed Description

Intravenous artesunate is egual to quinine in the treatment of severe malaria in the form of fever clearance time and parasite clearance time

Study Timeline

• Status Verified: 2013-03
• Study Start: 2013-03
• Study First Submitted: 2013-03-02
• Study First Submitted QC: 2013-03-04
• Last Update Submitted: 2013-03-04
• Study First Posted: 2013-03-06
• Last Update Posted: 2013-03-06
• Primary Completion: 2013-05
• Study Completion: 2013-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

severe P.falciparum malaria-

Exclusion Criteria

mixed infection Pregnant women -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
artesunate	artesunate	intravenous artesunate 80 mg/kg initially then after 8 hours then daily
artesunate	Quinine	intravenous artesunate 80 mg/kg initially then after 8 hours then daily
quinine	artesunate	quinine infusion 80 mg/kg every 8 hours
quinine	Quinine	quinine infusion 80 mg/kg every 8 hours

Primary Outcome Measures

Name	Time	Method
clearance of the parasite and fever	3 days	To compare the parasite clearance time and fever clearance time between the two groups

Trial Locations

Locations (1)

Kassala; 🇸🇩 Kassala, Sudan