Research Plan for Early Disease Screening Biomarkers in Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Blood routine test
研究概览
简要总结
The establishment of reference intervals for biomarkers in healthy populations relies on large-scale, standardized cohort data. However, current baseline data for hematology, liver and kidney function, and multi-omics (genomics, transcriptomics, proteomics, and metabolomics) in Chinese healthy populations are constrained by significant regional disparities and insufficient sample sizes, limiting the development of early disease screening markers. To address these challenges, this study aims to: (1) establish a comprehensive database for hematology and liver/kidney function indicators; (2) construct a multi-omics database using blood and sputum samples; and (3) explore the correlations among multi-omics indicators and their associations with demographic characteristics.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 18 - 65 years old, gender not restricted;
- •No clear history of chronic diseases (hypertension, diabetes, cardiovascular and cerebrovascular diseases, chronic liver and kidney diseases, tumors, etc.);
- •No infection history in the past 3 months (fever, cough, sore throat, etc.);
- •No use of antibiotics, hormones, immunosuppressants, etc. within the past 1 month;
- •Voluntarily sign the informed consent form and cooperate to complete the follow-up.
排除标准
- •Abnormal laboratory indicators (ALT/AST > 2 times the upper limit of normal value, Cr > upper limit of normal value, main indicators of blood routine test are abnormal and have clinical significance);
- •Pregnant or lactating women;
- •Recent (within 3 months) history of surgery, trauma or blood transfusion;
- •Mental illness or cognitive impairment that makes it impossible to cooperate with the research.
研究组 & 干预措施
Health
healthy populations
结局指标
主要结局
Blood routine test
时间窗: At the time of enrollment
次要结局
- Liver function(At the time of enrollment)
- renal function(At the time of enrollment)
研究者
Zhonghao Fang
Doctor
Guangzhou Medical University