Early Enteral Glutamine Supplement to Enteral Nutrition Support of the Major Torso Trauma Patient: Proposal for a Prospective Randomized Clinical Trial
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Gut function
研究概览
简要总结
Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. We hypothesize that for the major torso trauma patient, high dose glutamine given enterally during resuscitation from shock and continued during enteral nutrition support is absorbed, available systemically and preserves gut integrity.
详细描述
In this prospective, randomized, controlled trial of patients with major torso trauma, high-dose enteral glutamine and enteral nutrition will be given to research subjects while controls will receive isocaloric, isonitrogenous enteral support. Enteral tolerance, bowel integrity and permeability will be evaluated. The systemic appearance of glutamine will be measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult trauma patients meeting criteria for shock resuscitation
- •Major torso trauma
- •Admission to the Shock/Trauma Intensive Care Unit
排除标准
- •Age <18 years
- •Expected survival < 24 hours
- •Bowel in discontinuity
- •Renal failure: baseline serum creatinine>3.0 and/or dialysis
- •Admission total bilirubin >10 mg/dl
- •History of cirrhosis or cirrhosis apparent on exploratory laparotomy
- •Asystole or CPR required
结局指标
主要结局
Gut function
次要结局
- Systemic appearance of glutamine