NCT00677976已完成不适用
Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation Following Rectal Stimulation in Children With Irritable Bowel Syndrome
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- We intend to measure the degree of brain activation following rectal stimulation
研究概览
简要总结
The purpose of the study is to map regions of brain activation following rectal stimulation in children with irritable bowel syndrome (IBS) and healthy controls.
详细描述
Our first aim is to compare the brain areas activated rectal stimulation in boys and girls with IBS and healthy children. Our second aim is to compare the anatomic regions of the brain activated during rectal stimulation in pre and post-pubertal male and female subjects between 10-18 yrs of age.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children aged 10 years to 18 years who provide written assent and whose parents provide written permission for participation
- •English-speaking
- •Subjects in the IBS group will meet Rome III criteria for IBS as determined by a pediatric gastroenterologist.
排除标准
- •Other pain-related diseases, functional gastrointestinal disorders, or somatization disorder
- •Mental retardation or pervasive developmental disorder or epilepsy
- •Psychosis
- •Genetic or chromosomal disorders
- •Currently receiving psychoactive drug treatment
- •Patients with pacemakers, metal clips used in previous surgery or other device which are not compatible with MRI scanning
- •Inability to lie still in the scanner
- •Claustrophobia (Inability to lie still in the scanner)
- •Pregnancy
- •Subjects who admit to substance abuse during screening
- •Orthodontic braces
结局指标
主要结局
We intend to measure the degree of brain activation following rectal stimulation
时间窗: 4 years
次要结局
未报告次要终点
研究者
Manu Sood
Chief, Associate Professor
Medical College of Wisconsin
研究点 (1)
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