The Reproducibility and Clinical Utility of an Abbreviated Fat Tolerance Test

Not Applicable

Completed

• Conditions: Dyslipidemias; Metabolic Syndrome
• Interventions: Other: High-fat shake; Other: Pure glucose solution

• Registration Number: NCT04437459
• Lead Sponsor: Oklahoma State University

Brief Summary

This study aims to evaluate the reliability of a shortened fat tolerance test ("abbreviated fat tolerance test", or "AFTT") for measuring post-meal lipids in human blood. The reliability of the triglyceride results in this test are compared to the reliability of the glucose results from an oral glucose tolerance test (OGTT), a widely-used and clinically accepted metabolic test.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-08
• Primary Completion: 2019-07-31
• Study Completion: 2019-07-31
• Status Verified: 2020-06
• Study First Submitted: 2020-06-15
• Study First Submitted QC: 2020-06-16
• Last Update Submitted: 2020-06-16
• Study First Posted: 2020-06-18
• Last Update Posted: 2020-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Free of chronic disease
• Normal (healthy) fasting glucose and triglycerides

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Exclusion Criteria

• Presence of pace-maker
• Pregnant
• Using tobacco products
• Using medications or dietary supplements that could modify primary outcomes

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Abbreviated Fat Tolerance Test	High-fat shake	-
Oral Glucose Tolerance Test	Pure glucose solution	-

Primary Outcome Measures

Name	Time	Method
Reliability of the Change in Glucose after Ingestion of a Glucose Solution	The two glucose tolerance tests are separated by 1 week.	Participants complete two glucose tolerance tests. In each test, glucose is measured in blood immediately before and 2 hours after consumption of a pure glucose solution. The reliability/agreement in measuring the glucose change between the 2 tests is being determined.
Reliability of the Change in Triglycerides after a High-Fat Meal	The two fat tolerance tests are separated by 1 week.	Participants complete two fat tolerance tests. In each test, triglycerides are measured in blood immediately before and 4 hours after consumption of a high-fat meal. The reliability/agreement in measuring the triglyceride change between the 2 tests is being determined.

Trial Locations

Locations (1)

Oklahoma State University; 🇺🇸 Stillwater, Oklahoma, United States