Imaging the Arterial Pathology in Cerebral Small Vessel Disease Using 7 Tesla Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- Range and pattern of pathology seen in the perforating arteries like presence or absence of focal atheroma and narrowing
研究概览
简要总结
CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust.
We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Symptomatic lacunar stroke with corresponding lacunar infarct on MRI
排除标准
- •Unable/unwilling to consent;
- •Stroke aetiology due to cardio-embolism or large vessel disease;
- •Lacunar infarcts >1.5cm;
- •Severe stroke (NIHSS score ≥16);
- •Evidence of cortical infarct of any size;
- •Other major neurological diseases;
- •Severe systemic diseases such as heart failure, liver failure and kidney failure or any illness in the judgement of the investigator that could affect participation in the study;
- •MRI contraindications e.g. metal objects in or on the body, claustrophobia, pregnancy, known allergy to gadolinium containing contrast agent, impaired renal function with estimated glomerular filtration rate (eGFR) <59ml/min/1.73m2.
结局指标
主要结局
Range and pattern of pathology seen in the perforating arteries like presence or absence of focal atheroma and narrowing
时间窗: March 2020-
次要结局
- Correlation of morphology of perforating arteries with cardiovascular risk factors and radiological markers of SVD(March 2020-)
- Differences in morphology of perforating arteries between SVD patients and healthy volunteers(March 2020-)
研究者
Christopher Osuafor
Study Co-ordinator and Co-investigator
University of Cambridge