Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids

Phase 4

• Conditions: Asthma Exacerbation

• Registration Number: NCT00397267
• Lead Sponsor: Soroka University Medical Center

Brief Summary

We assume that the combination of systemic steroids and inhaled steroid in the first hour of treatment in the ER will decrease the admission rate and improve faster the pulmonary function.

120 patients refferd to the ER due to asthma attack aged 18-60 with PFR \< 60% 0o predicted will participate in the study after giving informed consent.

The usual treatment in the ER is inhalation of Beta 2 short acting and I.V solumedrol 120 mg . The study group will recieve in addition 3 inhalation of Budesonide 1000 microgram each during the first hour.

The controlled group will recieve Nacl 0.9% PFR will be followed 0 30 60 120 min.

Detailed Description

Primary end points- PFT improvment and admission rate.

Study Timeline

• Status Verified: 2006-10
• Study First Submitted: 2006-11-08
• Study First Submitted QC: 2006-11-08
• Study First Posted: 2006-11-09
• Last Update Submitted: 2006-11-26
• Last Update Posted: 2006-11-28
• Study Start: 2007-01
• Study Completion: 2007-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Asthmatic patients aged 18-60 with PFR < 60% of predicted

Exclusion Criteria

• Patients with other chronic diseases
• cardiac renal hepatic etc will be excluded

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
PFT improvment
Admission rate

Trial Locations

Locations (1)

ER Soroka Med Center; 🇮🇱 Beer-Sheva, Israel