Comparative Evaluation of the Effectiveness of Gas Combination Cryotherapy (using a refrigerant spray of propane, butane and isobutane) and 5-Fluorouracil Following Enucleation and Curettage in Management of Odontogenic Keratocyst

The
study will be a single-blinded, randomized, hospital-based clinical study.

 The intervention study will be carried out on patients visiting the Oral and Maxillofacial Surgery outpatient department, undergoing the enucleation and curettage of OKC.

 The subjects who are willing to participate in study will be selected serially during the study period as per the inclusion and exclusion criteria.

ASSESSMENT OF

·      

1. PAIN

·       2. WOUND DEHISCENCE, INFECTION AND NECROSIS

·       3. SOFT TISSUE HEALING

·       4. HARD TISSUE HEALING

·       5. RECURRENCE

·       6. NEUROSENSORY DEFICIT

·

Will be done by the Primary Investigator & the Co-Investigators

Follow-up on post-operative days 1st day,7th day, 14th, 1 month, 3 months & 8 months.

 Randomization of participants into two groups will be carried out as per computer generated list of random numbers into one of two as group A and group B. Participant will not be aware of the group in which he/she is included.

·       GROUP A (Control Group): Patients having OKCs who receive 5-Fluorouracil as the adjunctive therapy

·       GROUP B (Study Group): Patients having OKCs who receive Gas Combination Cryotherapy (GCC) as the adjunctive therapy

 Willing participants who meet the inclusion criteria will be informed about the benefits and risks associated with the procedure after which a written, valid, informed consent will be taken from all the patients.