Eating Disorders Genetics Initiative (EDGI)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 17,991
- Locations
- 3
- Primary Endpoint
- Number of Participants Identified with an Eating Disorder Diagnosis by Category
Study Overview
Brief Summary
The overarching intention of the Eating Disorder Genetics Initiative (EDGI) is to lay the foundation for all future genomic discovery in eating disorders--anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)--by exploring both genetic and behavioral factors. To do this, information will be collected from 4000 people who have provided DNA samples for the Anorexia Nervosa Genetics Initiative (ANGI) and the same information and DNA will be collected from an additional 16,000 people. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 15 Years to 99 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, or no history of any disordered eating behavior
- •Age 15-99 years
Exclusion Criteria
- •History of subthreshold disordered eating behaviors
Outcomes
Primary Outcomes
Number of Participants Identified with an Eating Disorder Diagnosis by Category
Time Frame: Baseline
The ED100K is a web-based diagnostic questionnaire, based on the Structured Clinical Interview for Axis 1 Disorders, that applies algorithms to participant responses. The number of participants with each diagnosis (AN, BN, BED, and control) will be reported.
Age of eating disorder onset
Time Frame: Baseline
Age of eating disorder onset will be considered as the age of first eating disorder symptom as self-reported in the ED100K questionnaire (ED100K). Age of onset will be reported for each eating disorder group.
Secondary Outcomes
- Current eating disorder self-report total sum scores(Baseline)
- Eating disorder-related quality of life scores(Baseline)
- Health-related quality of life scores(Baseline)
- Prevalence of life-time history of major depression(Baseline)
- Prevalence of generalized anxiety disorder(Baseline)
- Current depressive symptoms sum score(Baseline)
- Current anxiety symptoms sum scores(Baseline)