A Comparison of the Effectiveness of Thimerosal and Boric Acid Powder with Ofloxacin in the Treatment of Otitis Externa

Phase 3

Completed

• Conditions: patients who diagnosed acute otitis externaage older than 18 years; acute otitis externa; thimerosal; boric acid powder; ofoxacin

• Registration Number: TCTR20230316003
• Lead Sponsor: Department of Otolaryngology Faculty of Medicine Ramathibodi Hospital Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-11-30
• Study Start: 2023-03-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

patients who diagnosed acute otitis externa
age older than 18 years

Exclusion Criteria

perforated tympanic membrane on the affected side
dermatitis
acute otitis media
history of receiving antibiotic or steroid in the previous month
malignant otitis externa
severe acute otitis externa (CSS > 10)
history of hypersensitivity reaction to thimerosal, boric acid powder, ofloxacin otic drop, or 10% xylocaine spray
on immunosuppressant

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in clinical symptom score between two groups at day 3, 7 and 14 post treatment day 3, 7 and 14 clinical symptom score

Secondary Outcome Measures

Name	Time	Method
Change in VAS between two groups at day 3, 7 and 14 post treatment day 3, 7 and 14 VAS (aural fullness, otalgia, itching, hearing)