Reducing 'bubbles' (gaseous micro-emboli) circulating in the blood system during open heart surgery

Not Applicable

• Conditions: Cardiothoracic Surgery; Surgery

• Registration Number: ISRCTN87042095
• Lead Sponsor: niversity Hospitals Bristol and Western NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-06-13
• Last Update Posted: 8 May 2023
• Study Completion: 2024-04-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Age > = 40 years
2. Having elective or urgent CABG or AVR (with or without an associated CABG procedure AVR±CABG) via a partial or full sternotomy using using central aortic perfusion cannulae CPB.

Exclusion Criteria

1. History of clinical stroke within 3 months prior to randomization
2. Cardiac catheterisation within 3 days of the planned surgery
3. Cerebral and/or aortic arch arteriography or interventions within 3 days of the planned surgery
4. Active endocarditis at time of randomisation
5. Planned concomitant aortic procedure such as root replacement
6. Clinical signs of cardiogenic shock or treatment with IV inotropic therapy prior to randomization
7. Myocardial infarction in the previous 4 days
8. Participation in an interventional (drug or device) trial
9. Unable to provide written informed consent
10. Prisoner

Study & Design

• Study Type: Interventional
• Study Design: Not specified