Verification of the clinical usefulness and the safety of the egg activation by PLCZ1 mRNA injection after intracytoplasmic injection using round spermatids from azoospermic men.
Not Applicable
Recruiting
- Conditions
- Azoospermia
- Registration Number
- JPRN-UMIN000020860
- Lead Sponsor
- Saint Mother Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1. In the case when even once a few spermatozoa have been found even if no spermatozoa are observed in other frequent analysis. 2. In the case when the possibility of obtaining round spermatids is near zero. 3. In the case when the surgical procedure for round spermatid collection is likely to deteriorate the patient's health. 4. In the case when the number of collected oocytes from patient's wife is less than five.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the pregnancy rate per cycles and miscarriage rate
- Secondary Outcome Measures
Name Time Method Rate of preimplantation development Rate of PLCZ1 mRNA decay, Array CGH Methylation profile mRNA expression profile Birth rate