EUCTR2007-006234-34-GBActive, not recruitingNot Applicable
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: endothelial and endothelial progenitor cell function in men - Simvastatin and endothelial function in men
niversity of Leeds0 sitesStarted: July 15, 2008Last updated:
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional clinical trial of medicinal product
Eligibility Criteria
- Sex
- Male
Inclusion Criteria
- •We will recruit sedentary
- •* Age 18 to 40 years
- •* Body mass index <30 kg/m2
- •* Normotensive
- •* Non-diabetic
- •* Non-smokers
- •* Normal liver function, haematology and cholesterol.
- •Healthy subjects will be identified by taking a medical history at the preliminary visit by a medically qualified researcher.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
Exclusion Criteria
- •* Female gender
- •* Age <18 or >40 years
- •* Hypertension
- •* Diabetes mellitus
- •* Current smokers
- •* Liver disease (including abnormal liver function tests and / or a history of liver disease)
- •* Alcohol abuse
- •* Ischaemic heart disease
- •* Unwilling to refrain from drinking grapefruit juice
- •* Currently taking statins
- •* Contraindications to statins (according to the British National Formulary and assessed by taking a history and blood tests at the preliminary visit).
- •* Ingestion of large quantities of grapefruit juice
- •* Participating in another trial or have done so in the last 30 days
Investigators
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